Detection of cancer cells in body fluids
A method of detecting circulating melanoma or carcinoma cells in a subject. The method comprises obtaining a body fluid from a subject and detecting the expression of a panel of genes in the body fluid, wherein the expression of the panel of genes indicates the presence of circulating melanoma or carcinoma cells in the subject. Genes useful for detecting melanoma cells includes GalNAc-T, MAGE-A3, MART-1, PAX-3, and TRP-2; genes useful for detecting carcinoma cells include C-Met, MAGE-A3, Stanniocalcin-1, Stanniocalcin-2, mammaglobin, HSP27, GalNAc-T, CK20, and .beta.-HCG. Also disclosed are kits containing agents for detecting the expression of these genes.
John Wayne Cancer Institute (Santa Monica, CA)
Hoon, Dave S B, "Detection of cancer cells in body fluids" (2005). Technology Transfer - Patents. 47.