Title

Immunogenic compositions comprising silicified virus and methods of use

Inventors

Kenneth M. Stedman
James R. Laidler
Keith Bahjat

Document Type

Patent

File Date

7-28-2015

Abstract

It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.

Department

Allergy & Immunology

Location

United States

Comments

Patent Number: 9,993,543

Assignee

Portland State University (Portland, OR); Providence Health & Services--Oregon (Portland, OR)

Family ID

51263001

Serial Number

14/763,947

Tech ID

12-02-INV-F

Recommended Citation

Stedman, Kenneth M.; Laidler, James R.; and Bahjat, Keith, "Immunogenic compositions comprising silicified virus and methods of use" (2015). Technology Transfer - Patents. 30.
https://digitalcommons.providence.org/technologytransfer/30