Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.)
Adult; Aged; Biopsy, Needle; Body Mass Index; Databases, Factual; Elasticity Imaging Techniques; Female; Humans; Immunohistochemistry; Logistic Models; Male; Middle Aged; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Obesity; Observer Variation; Retrospective Studies; Risk Assessment; Severity of Illness Index; Task Performance and Analysis; Vibration
Vibration-controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis and steatosis, respectively. However, prior vibration-controlled transient elastography studies reported high failure rates in patients with nonalcoholic fatty liver disease. We examined the performance characteristics of the FibroScan 502 Touch with two probes, medium (M+) and extra large (XL+), in patients with nonalcoholic fatty liver disease in a multicenter setting. A total of 1,696 exams were attempted in 992 patients (body mass index, 33.6 ± 6.5 kg/m
CONCLUSION: Vibration-controlled transient elastography for estimation of LSM and CAP can be successfully deployed in a multicenter setting with low failure (3.2%) and high reliability (>95%) rates and high reproducibility. (Hepatology 2018;67:134-144).
Vuppalanchi, Raj; Siddiqui, Mohammad S; Van Natta, Mark L; Hallinan, Erin; Brandman, Danielle; Kowdley, Kris; Neuschwander-Tetri, Brent A; Loomba, Rohit; Dasarathy, Srinivas; Abdelmalek, Manal; Doo, Edward; Tonascia, James A; Kleiner, David E; Sanyal, Arun J; and Chalasani, Naga, "Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease." (2018). Articles, Abstracts, and Reports. 97.