Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial.
Journal of the American Society of Nephrology : JASN
Chronic inflammation; chronic kidney disease; diet; exercise; metabolism; oxidative stress
CKD is steadily increasing along with obesity worldwide. Furthermore, obesity is a proinflammatory risk factor for progression of CKD and cardiovascular disease. We tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and can improve the proinflammatory metabolic milieu in patients with moderate to severe CKD through a pilot, randomized, 2×2 factorial design trial. Of 122 participants consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or usual care. Of those randomized, 42% were women, 25% were diabetic, and 91% were hypertensive; 104 started intervention, and 92 completed the 4-month study. Primary outcomes were a change from baseline in absolute fat mass, body weight, plasma F
Kidney & Diabetes
Ikizler, T Alp; Robinson-Cohen, Cassianne; Ellis, Charles; Headley, Samuel A E; Tuttle, Katherine; Wood, Richard J; Evans, Elizabeth Elspeth; Milch, Charles M; Moody, Kelsey Anne; Germain, Michael; Limkunakul, Chutatip; Bian, Aihua; Stewart, Thomas G; and Himmelfarb, Jonathan, "Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial." (2018). Articles, Abstracts, and Reports. 90.