Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.

Authors

Marka R Crittenden, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, PortlandFollow
Lauren Zebertavage
Gwen Kramer, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, PortlandFollow
Shelly Bambina, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, PortlandFollow
David Friedman, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA.
Victoria Troesch, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA.
Tiffany Blair
Jason R Baird, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, PortlandFollow
Alejandro F Alice, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, PortlandFollow
Michael J Gough, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA.Follow

Document Type

Article

Publication Date

5-3-2018

Abstract

Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell responses. To evaluate the immune response initiated by radiation therapy, we used a range of approaches to block the pre-existing immune response artifact initiated by tumor implantation. We demonstrate that blocking immune responses at tumor implantation blocks development of a tumor-resident antigen specific T cell population and prevents tumor cure by radiation therapy combined with checkpoint immunotherapy. These data demonstrate that this treatment combination relies on a pre-existing immune response to cure tumors, and may not be a solution for patients without pre-existing immunity.

Clinical Institute

Cancer

Department

Oncology

Department

Earle A. Chiles Research Institute

Recommended Citation

Crittenden, Marka R; Zebertavage, Lauren; Kramer, Gwen; Bambina, Shelly; Friedman, David; Troesch, Victoria; Blair, Tiffany; Baird, Jason R; Alice, Alejandro F; and Gough, Michael J, "Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity." (2018). Articles, Abstracts, and Reports. 824.
https://digitalcommons.providence.org/publications/824