Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma.
Alcohols; Anti-cancer drugs; Glioblastoma
Glioblastoma remains the most common and aggressive type of malignant brain tumor among adults thus, considerable attention has been given to discovery of novel anti-tumor drugs for its treatment. This study reports the synthesis of a series of twelve novel decane-1,2-diol derivatives and evaluation of its anti-tumor activity in mammalian glioblastoma cell lines, U87 and LN229. Starting from decane-1,2-diol, several derivatives were prepared using a diversity oriented synthesis approach through which a small library composed of esters, silyl ethers, sulfonates, sulfites, sulfates, ketals, and phosphonates was built. The decane-1,2-diol ditosylated derivative, DBT, found to have higher cytotoxicity than the standard drug cisplatin, has IC
Institute for Systems Biology
Viswanathan, Anisha; Zhurina, Anastasia; Assoah, Benedicta; Paakkunainen, Aleksi; Musa, Aliyu; Kute, Dinesh; Saravanan, Konda Mani; Yli-Harja, Olli; Candeias, Nuno R; and Kandhavelu, Meenakshisundaram, "Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma." (2018). Articles, Abstracts, and Reports. 743.