Title

Biological BMI uncovers hidden health risks and is more responsive to lifestyle shifts

Document Type

Article

Publication Date

4-11-2023

Publication Title

Nature Medicine

Keywords

washington; isb

Abstract

Body mass index (BMI) is a clinically useful obesity measure that shows an association with healthspan and lifespan. We developed ‘biological BMI’ scores, calculated from multi-omics data (proteins and metabolites) and clinical laboratory tests from blood. We show that a biological BMI more accurately reflects metabolic health and is more responsive to lifestyle changes than a classically measured BMI.

Clinical Institute

Digestive Health

Department

Institute for Systems Biology

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