Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.

Authors

Bernard A Fox, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, United States.Follow
Walter J Urba, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, United States.Follow
Shawn M Jensen, Earle A. Chiles Research Institute, Portland, OR, United States.Follow
David B Page, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, United States.Follow
Brendan D Curti, Providence Cancer Institute and Earle A. Chiles Research Institute, Portland, OR, United States.Follow
Rachel E Sanborn, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, Oregon, United States.Follow
Rom S Leidner, Providence Cancer Institute, Portland, OR, United States.Follow

Document Type

Article

Publication Date

4-11-2023

Publication Title

Clinical cancer research : an official journal of the American Association for Cancer Research

Keywords

oregon; chiles

Abstract

The authors of a recent study identified non-canonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens.

Clinical Institute

Cancer

Department

Oncology

Department

Earle A. Chiles Research Institute

Recommended Citation

Fox, Bernard A; Urba, Walter J; Jensen, Shawn M; Page, David B; Curti, Brendan D; Sanborn, Rachel E; and Leidner, Rom S, "Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies." (2023). Articles, Abstracts, and Reports. 7231.
https://digitalcommons.providence.org/publications/7231