Enhancement of anti-tumor efficacy of immune checkpoint blockade by alpha-TEA.

Document Type

Article

Publication Date

1-1-2023

Publication Title

Front Immunol

Keywords

oregon; chiles; Humans; Animals; Mice; Female; Immune Checkpoint Inhibitors; Immunotherapy; Breast Neoplasms; Cytokines

Abstract

Cancer immunotherapy such as anti-PD-1/anti-PD-L1 immune checkpoint blockade (ICB) can provide significant clinical benefit in patients with advanced malignancies. However, most patients eventually develop progressive disease, thus necessitating additional therapeutic options. We have developed a novel agent, a-TEA-LS, that selectively induces tumor cell death while sparing healthy tissues, leading to increased activation of tumor-reactive T cells and tumor regression. In the current study, we explored the impact of combined a-TEA-LS + ICB in orthotopic and spontaneously arising murine models of mammary carcinoma. We found that a-TEA-LS + ICB led to increased production of pro-inflammatory cytokines that were associated with a reduction in tumor growth and prolonged survival. Together, these data demonstrate the potential utility of a-TEA-LS + ICB for the treatment of breast cancer and provide the rationale for clinical translation of this novel approach.

Clinical Institute

Cancer

Clinical Institute

Women & Children

Department

Oncology

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