Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.
Document Type
Article
Publication Date
12-16-2022
Publication Title
Adv Sci (Weinh)
Keywords
oregon; eacri; chiles
Abstract
Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.
Clinical Institute
Cancer
Department
Oncology
Department
Earle A. Chiles Research Institute
Recommended Citation
Wen, Di; Liang, Tingxizi; Chen, Guojun; Li, Hongjun; Wang, Zejun; Wang, Jinqiang; Fu, Ruxing; Han, Xiao; Ci, Tianyuan; Zhang, Yuqi; Abdou, Peter; Li, Ruoxin; Bu, Linlin; Dotti, Gianpietro; and Gu, Zhen, "Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy." (2022). Articles, Abstracts, and Reports. 6820.
https://digitalcommons.providence.org/publications/6820
