Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic.

Aarthi S Ganapathi, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Ryan M Glatt, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Tess H Bookheimer, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Emily S Popa, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Morgan L Ingemanson
Casey J Richards, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
John F Hodes, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Kyron P Pierce, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Colby B Slyapich, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Fatima Iqbal, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Jenna Mattinson, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Melanie G Lampa, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Jaya M Gill, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.. Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
Ynez M Tongson, Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Claudia L Wong, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Mihae Kim, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Verna R Porter, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Santosh Kesari, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA., Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
Somayeh Meysami, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
Karen J Miller, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
Jennifer E Bramen, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
David A Merrill, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA., Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
Prabha Siddarth, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow

Document Type

Article

Publication Date

1-1-2022

Publication Title

Journal of Alzheimer's disease : JAD

Keywords

california; sjci

Abstract

BACKGROUND: Distinguishing between subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia in a scalable, accessible way is important to promote earlier detection and intervention.

OBJECTIVE: We investigated diagnostic categorization using an FDA-cleared quantitative electroencephalographic/event-related potential (qEEG/ERP)-based cognitive testing system (eVox® by Evoke Neuroscience) combined with an automated volumetric magnetic resonance imaging (vMRI) tool (Neuroreader® by Brainreader).

METHODS: Patients who self-presented with memory complaints were assigned to a diagnostic category by dementia specialists based on clinical history, neurologic exam, neuropsychological testing, and laboratory results. In addition, qEEG/ERP (n = 161) and quantitative vMRI (n = 111) data were obtained. A multinomial logistic regression model was used to determine significant predictors of cognitive diagnostic category (SCD, MCI, or dementia) using all available qEEG/ERP features and MRI volumes as the independent variables and controlling for demographic variables. Area under the Receiver Operating Characteristic curve (AUC) was used to evaluate the diagnostic accuracy of the prediction models.

RESULTS: The qEEG/ERP measures of Reaction Time, Commission Errors, and P300b Amplitude were significant predictors (AUC = 0.79) of cognitive category. Diagnostic accuracy increased when volumetric MRI measures, specifically left temporal lobe volume, were added to the model (AUC = 0.87).

CONCLUSION: This study demonstrates the potential of a primarily physiological diagnostic model for differentiating SCD, MCI, and dementia using qEEG/ERP-based cognitive testing, especially when combined with volumetric brain MRI. The accessibility of qEEG/ERP and vMRI means that these tools can be used as adjuncts to clinical assessments to help increase the diagnostic certainty of SCD, MCI, and dementia.

Clinical Institute

Neurosciences (Brain & Spine)

Clinical Institute

Mental Health

Clinical Institute

Cancer

Department

Behavioral Health

Department

Oncology

Department

Neurosciences

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