TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer
Journal of clinical pathology
Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; CpG Islands; DNA Methylation; Disease-Free Survival; Female; Humans; Immunohistochemistry; Prognosis; Protein Isoforms; Tumor Protein p73
AIM: Accumulated evidence suggests that aberrant methylation of the
RESULTS: We observed that the methylation of diverse CpG islands of
CONCLUSIONS: Our findings suggest that high expression of ΔNp73 could be used to determine the aggressiveness of IDCs and could be incorporated in the pathologist's report.
Gomez, Laura C; Sottile, Mayra L; Guerrero-Gimenez, Martin E; Zoppino, Felipe C M; Redondo, Analia L; Gago, Francisco E; Orozco, Javier I; Tello, Olga M; Roqué, Maria; Nadin, Silvina B; Marzese, Diego M; and Vargas-Roig, Laura M, "TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer" (2018). Articles, Abstracts, and Reports. 67.