Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study.
Diabetes research and clinical practice
washington; spokane; pmrc
BACKGROUND: Baseline risk variables and visit-to-visit variability (VV) of systolic blood pressure (SBP), HbA
METHODS: Post-hoc analysis of a double-blind randomized placebo-controlled clinical trial investigating allopurinol's effect on iohexol-derived glomerular filtration rate (iGFR) in type 1 diabetes with elevated UA. Primary outcome was iGFR change over three years. Linear regression with backwards selection of baseline clinical variables was performed to identify an optimized model forecasting iGFR change. Furthermore, VVs of SBP, HbA
RESULTS: 404 participants were included in the primary analyses. In the optimized baseline variable model, higher HbA
CONCLUSIONS: We identified several risk markers for faster iGFR decline in a high-risk population with type 1 diabetes. While further research is needed, our results indicate possible new and clinically feasible measures to risk stratify for DKD in type 1 diabetes.
Kidney & Diabetes
Rotbain Curovic, Viktor; Roy, Neil; Hansen, Tine W; Luiza Caramori, M; Cherney, David Z; De Boer, Ian H; Emanuele, Mary Ann; Hirsch, Irl B; Lingvay, Ildiko; Mcgill, Janet B; Polsky, Sarit; Pop-Busui, Rodica; Sigal, Ronald J; Tuttle, Katherine R; Umpierrez, Guillermo E; Wallia, Amisha; Rosas, Sylvia E; Rossing, Peter; and Study Group, PERL, "Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study." (2022). Articles, Abstracts, and Reports. 6595.