Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium.
cancer epidemiology; inflammation; inflammatory mediators; oesophageal cancer
OBJECTIVE: Cross-sectional data indicate that systemic inflammation is important in oesophageal adenocarcinoma. We conducted a prospective study to assess whether prediagnostic circulating markers of inflammation were associated with oesophageal adenocarcinoma and to what extent they mediated associations of obesity and cigarette smoking with cancer risk.
DESIGN: This nested case-control study included 296 oesophageal adenocarcinoma cases and 296 incidence density matched controls from seven prospective cohort studies. We quantitated 69 circulating inflammation markers using Luminex-based multiplex assays. Conditional logistic regression models estimated associations between inflammation markers and oesophageal adenocarcinoma, as well as direct and indirect effects of obesity and smoking on risk of malignancy.
RESULTS: Soluble tumour necrosis factor receptor 2 (sTNFR2) (ORs
CONCLUSION: This prospective study provides evidence of a link between systemic inflammation and oesophageal adenocarcinoma risk. In addition, this study provides the first evidence that indirect effects of excess adiposity and cigarette smoking, via systemic inflammation, increase the risk of oesophageal adenocarcinoma.
Cook, Michael B; Barnett, Matthew J; Bock, Cathryn H; Cross, Amanda J; Goodman, Phyllis J; Goodman, Gary E; Haiman, Christopher A; Khaw, Kay-Tee; McCullough, Marjorie L; Newton, Christine C; Boutron-Ruault, Marie-Christine; Lund, Eiliv; Rutegård, Martin; Thornquist, Mark D; Spriggs, Michael; Giffen, Carol; Freedman, Neal D; Kemp, Troy; Kroenke, Candyce H; Le Marchand, Loïc; Park, Jin Young; Simon, Michael; Wilkens, Lynne R; Pinto, Ligia; Hildesheim, Allan; and Campbell, Peter T, "Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium." (2018). Articles, Abstracts, and Reports. 647.