Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement.

Authors

Thomas E Ichim
Santosh Kesari, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Kim Shafer

Document Type

Article

Publication Date

7-20-2018

Publication Title

Oncotarget

Keywords

cancer; chemotherapy; digestive enzymes; microbiome; probiotic

Abstract

There are numerous downstream consequences of marketed drugs like antineoplastic agents on the gut microbiome, an effect that is suggested to contribute to adverse event profiles and may also influence drug responses. In cancer, progress is needed toward modulation of the host microbiome to prevent off-target side effects of drugs such as gastrointestinal mucositis that result from gut dysbiosis. The objective of this study was evaluation of the bioactivity of a supplement consisting of capsules with a blend of 9 probiotic organisms of the genera

Clinical Institute

Cancer

Department

Oncology

Recommended Citation

Ichim, Thomas E; Kesari, Santosh; and Shafer, Kim, "Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement." (2018). Articles, Abstracts, and Reports. 641.
https://digitalcommons.providence.org/publications/641