PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T
Document Type
Article
Publication Date
5-1-2022
Publication Title
Nat Metab
Keywords
Aging; Animals; Homeostasis; Mice; Oxidoreductases; Parkinson Disease; Protein Deglycase DJ-1; Pyruvates; T-Lymphocytes, Regulatory
Abstract
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4
Clinical Institute
Neurosciences (Brain & Spine)
Department
Institute for Systems Biology
Department
Neurosciences
Recommended Citation
Danileviciute, Egle; Zeng, Ni; Capelle, Christophe M; Paczia, Nicole; Gillespie, Mark A; Kurniawan, Henry; Benzarti, Mohaned; Merz, Myriam P; Coowar, Djalil; Fritah, Sabrina; Vogt Weisenhorn, Daniela Maria; Gomez Giro, Gemma; Grusdat, Melanie; Baron, Alexandre; Guerin, Coralie; Franchina, Davide G; Léonard, Cathy; Domingues, Olivia; Delhalle, Sylvie; Wurst, Wolfgang; Turner, Jonathan D; Schwamborn, Jens Christian; Meiser, Johannes; Krüger, Rejko; Ranish, Jeff; Brenner, Dirk; Linster, Carole L; Balling, Rudi; Ollert, Markus; and Hefeng, Feng Q, "PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T" (2022). Articles, Abstracts, and Reports. 6363.
https://digitalcommons.providence.org/publications/6363
