Authors

Xuemei Ji
Yohan Bossé
Maria Teresa Landi
Jiang Gui
Xiangjun Xiao
David Qian
Philippe Joubert
Maxime Lamontagne
Yafang Li
Ivan Gorlov
Mariella de Biasi
Younghun Han
Olga Gorlova
Rayjean J Hung
Xifeng Wu
James McKay
Xuchen Zong
Robert Carreras-Torres
David C Christiani
Neil Caporaso
Mattias Johansson
Geoffrey Liu
Stig E Bojesen
Loic Le Marchand
Demetrios Albanes
Heike Bickeböller
Melinda C Aldrich
William S Bush
Adonina Tardon
Gad Rennert
Chu Chen
M Dawn Teare
John K Field
Lambertus A Kiemeney
Philip Lazarus
Aage Haugen
Stephen Lam
Matthew B Schabath
Angeline S Andrew
Hongbing Shen
Yun-Chul Hong
Jian-Min Yuan
Pier A Bertazzi
Angela C Pesatori
Yuanqing Ye
Nancy Diao
Li Su
Ruyang Zhang
Yonathan Brhane
Natasha Leighl
Jakob S Johansen
Anders Mellemgaard
Walid Saliba
Christopher Haiman
Lynne Wilkens
Ana Fernandez-Somoano
Guillermo Fernandez-Tardon
Erik H F M van der Heijden
Jin Hee Kim
Juncheng Dai
Zhibin Hu
Michael P A Davies
Michael W Marcus
Hans Brunnström
Jonas Manjer
Olle Melander
David C Muller
Kim Overvad
Antonia Trichopoulou
Rosario Tumino
Jennifer Doherty
Gary E Goodman, Swedish Medical Group, Arnold Pavilion, Suite 200, Seattle, 98104, WA, USA.Follow
Angela Cox
Fiona Taylor
Penella Woll
Irene Brüske
Judith Manz
Thomas Muley
Angela Risch
Albert Rosenberger
Kjell Grankvist
Mikael Johansson
Frances Shepherd
Ming-Sound Tsao
Susanne M Arnold
Eric B Haura
Ciprian Bolca
Ivana Holcatova
Vladimir Janout
Milica Kontic
Jolanta Lissowska
Anush Mukeria
Simona Ognjanovic
Tadeusz M Orlowski
Ghislaine Scelo
Beata Swiatkowska
David Zaridze
Per Bakke
Vidar Skaug
Shanbeh Zienolddiny
Eric J Duell
Lesley M Butler
Woon-Puay Koh
Yu-Tang Gao
Richard Houlston
John McLaughlin
Victoria Stevens
David C Nickle
Ma'en Obeidat
Wim Timens
Bin Zhu
Lei Song
María Soler Artigas
Martin D Tobin
Louise V Wain
Fangyi Gu
Jinyoung Byun
Ahsan Kamal
Dakai Zhu
Rachel F Tyndale
Wei-Qi Wei
Stephen Chanock
Paul Brennan
Christopher I Amos

Document Type

Article

Publication Date

8-13-2018

Publication Title

Nat Commun

Abstract

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

Clinical Institute

Cancer

Department

Oncology

Department

Pulmonary Medicine

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