Autoimmune Hemolytic Anemia in Children: Laboratory Investigation, Disease Associations, and Treatment Strategies.

Document Type

Article

Publication Date

4-1-2022

Publication Title

Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology

Keywords

oregon; portland; Anemia, Hemolytic, Autoimmune; Autoantibodies; Autoimmune Diseases; Child; Hemoglobinuria, Paroxysmal; Humans; Seasons

Abstract

Autoimmune hemolytic anemia is a relatively uncommon pediatric clinical condition. As such, the evaluation and management of these cases can be challenging for even the most seasoned pediatrician. In this review, the 3 major forms of autoimmune hemolytic anemia in children will be discussed: warm autoimmune hemolytic anemia, cold agglutinin disease, and paroxysmal cold hemoglobinuria. After a general description of the laboratory approach to these entities, the pathophysiology of these disease processes, including important disease associations, will be described, and treatment strategies will be discussed. This will provide the reader with a rational approach to identifying and managing pediatric patients with these uncommon autoimmune conditions.

Clinical Institute

Women & Children

Clinical Institute

Cancer

Department

Pathology & Laboratory Medicine

Department

Pediatrics

Department

Hematology

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