Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.

Document Type

Article

Publication Date

11-16-2021

Publication Title

Journal of the American College of Cardiology

Keywords

cards; cards publication; oregon; portland; Acute Coronary Syndrome; Adult; Aged; Algorithms; Contrast Media; Coronary Angiography; Dose-Response Relationship, Drug; Echocardiography; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Kinetics; Male; Microbubbles; Microcirculation; Middle Aged; Molecular Imaging; Myocardial Infarction; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardium; Percutaneous Coronary Intervention; Point-of-Care Systems; Young Adult

Abstract

BACKGROUND: Noninvasive molecular imaging of recent ischemia can potentially be used to diagnose acute coronary syndrome (ACS) with high accuracy.

OBJECTIVES: The authors hypothesized that bedside myocardial contrast echocardiography (MCE) ischemic memory imaging could be achieved with phosphatidylserine microbubbles (MB

METHODS: A dose-finding study was performed in healthy volunteers (n = 17) to establish optimal MB

RESULTS: Based on dose-finding studies, 0.10 or 0.15 mL of MB

CONCLUSIONS: Molecular imaging with point-of-care echocardiography and MB

Clinical Institute

Cardiovascular (Heart)

Department

Center for Cardiovascular Analytics, Research + Data Science (CARDS)

Department

Cardiology

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