A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project.
American journal of kidney diseases : the official journal of the National Kidney Foundation
An understanding of the ethical underpinnings of human subjects research that involves some risk to participants without anticipated direct clinical benefit-such as the kidney biopsy procedure as part of the Kidney Precision Medicine Project (KPMP)-requires a critical examination of risks as well as a diverse set of countervailing potential benefits to participants. This kind of deliberation has been foundational to the development and conduct of the KPMP. Herein, we use illustrative features of this research paradigm to develop a more comprehensive conceptualization of the types of benefits that may be important to research participants, including respecting pluralistic values, supporting the opportunity to act altruistically, and enhancing benefits to a participant's community. This approach may serve as a model to help researchers, ethicists, and regulators to identify opportunities to better respect and support participants in future research that entails some risk to these participants as well as to improve the quality of research for people with kidney disease.
Kidney & Diabetes
Butler, Catherine R; Appelbaum, Paul S; Ascani, Heather; Aulisio, Mark; Campbell, Catherine E; de Boer, Ian H; Dighe, Ashveena L; Hall, Daniel E; Himmelfarb, Jonathan; Knight, Richard; Mehl, Karla; Murugan, Raghavan; Rosas, Sylvia E; Sedor, John R; O'Toole, John F; Tuttle, Katherine; Waikar, Sushrut S; Freeman, Michael; and Kidney Precision Medicine Project, "A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project." (2021). Articles, Abstracts, and Reports. 5654.