High Resolution Manometry in a Functioning Fundoplication - Establishing a Standard Profile: Retrospective Chart Review.
Annals of surgery
oregon; portland; ppmc
OBJECTIVE: The aim of this study was to provide a full HRM data set in patients with a normal functioning fundoplication.
BACKGROUND: The Chicago classification was devised to correlate High Resolution Manometry (HRM) values to the clinical status of patients with swallowing disorder. However, it is unclear whether those values are applicable after fundoplication as the literature is sparse.
METHODS: We identified patients with pre- and postoperative HRM who had a normal functioning primary fundoplication as defined by 1) resolution of preoperative symptoms without significant postoperative side effects, 2) no dysphagia reported on a standardized questionnaire given on the day of the postoperative HRM and 3) normal acid exposure determined objectively by esophageal pH-testing.
RESULTS: Fifty patients met inclusion criteria for the study. Thirty-three patients (66%) underwent complete fundoplication and 17 patients (34%) underwent posterior partial fundoplication. Postoperative HRM was performed at a median of 12 months after primary surgery. LES values significantly increased with the addition of a fundoplication. Median IRP was 14mmHg (p = 0.0001), median resting pressure 19.5mmHg (p = 0.0263) and median total length LES was 3.95 cm (p = 0.0098). The 95th percentile for IRP in a complete fundoplication was 29 vs. 23mmHg in a partial fundoplication (p = 0.3667).
CONCLUSION: We offer a new standard manometric profile for a normally functioning fundoplication which provides a necessary benchmark for analyzing postoperative problems with a fundoplication. The previously accepted upper limit defining esophageal outflow obstruction (IRP > 20mmHg) is not clinically applicable after fundoplication as the majority of patients in this dysphagia-free cohort exceeded this value. Interestingly, there does not appear to be a significant difference in HRM LES values between complete and partial fundoplication.
Müller, Dolores T; Parker, Brett; Fletcher, Reid; Sharata, Ahmed M; Bradley, Daniel Davila; DeMeester, Steven R; Reavis, Kevin M; Swanstrom, Lee L; and Dunst, Christy M, "High Resolution Manometry in a Functioning Fundoplication - Establishing a Standard Profile: Retrospective Chart Review." (2021). Articles, Abstracts, and Reports. 5494.