Acute PR3-ANCA vasculitis in an asymptomatic COVID-19 teenager.

Document Type

Article

Publication Date

12-1-2021

Publication Title

J Pediatr Surg Case Rep

Keywords

washington; spokane; ANA, anti-nuclear antibody; ANCA; ANCA, antineutrophil cytoplasmic antibody; CMV, Cytomegalovirus; COVID-19; COVID-19, coronavirus disease 2019; EBV, Epstein-Barr virus; HSP, Henoch Schönlein Purpura; Henoch Schonlein purpura; IgG, immunoglobulin G; MIS-C, multisystem inflammatory syndrome in children; NSAIDs, Non-steroidal anti-inflammatory drugs; Vasculitis; anti-MPO, myeloperoxidase antibody; anti-PR3, proteinase 3 antibody

Abstract

We present the case of an acute onset ANCA positive vasculitis in an asymptomatic COVID-19 infected teenager, resulting in significant colonic damage. The patient was initially diagnosed with Henoch-Schönlein purpura and presented with worsening symptoms with significant necrosis of her perineum and rectum requiring surgical debridement and diverting colostomy. As a part of her work-up, she tested positive for COVID-19 total IgG/IgM antibodies and ANCA antibodies. This case complements previously reported cases of COVID-19 induced autoimmune disease in children but is novel in describing extensive intestinal disease as a result of an autoimmune vasculitis in a child.

Clinical Institute

Women & Children

Clinical Institute

Digestive Health

Department

Gastroenterology

Department

Pediatrics

Department

Surgery

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