Effects of radiation on tumor vasculature.

Document Type

Article

Publication Date

10-13-2021

Publication Title

Molecular carcinogenesis

Keywords

radiation; tumor vasculature; vascular normalization; vasculogenesis; oregon; portland; eacri

Abstract

Radiation has been utilized as a direct cytotoxic tumorcidal modality, however, the effect of radiation on tumor vasculature influences response to anticancer therapies. Although numerous reports have demonstrated vascular changes in irradiated tumors, the findings and implications are extensive and at times contradictory depending on the radiation dose, timing, and models used. In this review, we focus on the radiation-mediated effects on tumor vasculature with respect to doses used, timing postradiation, vasculogenesis, adhesion molecule expression, permeability, and pericyte coverage, including the latest findings.

Clinical Institute

Cancer

Department

Oncology

Department

Earle A. Chiles Research Institute

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