Journal of translational medicine [electronic resource]
Biomarkers; Combination strategies; Immunotherapy; Melanoma; Target therapy; genomics
Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape was revolutionised with the approval of the anti-cytotoxic T-lymphocyte-associated protein-4 checkpoint inhibitor ipilimumab and the selective BRAF kinase inhibitor vemurafenib, both of which significantly improved overall survival. Since then, availability of new immunotherapies, especially the anti-programmed death-1 checkpoint inhibitors, as well as other targeted therapies, have further improved outcomes for patients with advanced melanoma. Seven years on from the first approval of these novel therapies, evidence for the use of various immune-based and targeted approaches is continuing to increase at a rapid rate. Improved understanding of the tumour microenvironment and tumour immuno-evasion strategies has resulted in different approaches to target and harness the immune response. These new immune-based approaches offer the opportunity for various approaches with distinct modes of action being used in combination with one another, as well as combined with other treatment modalities such as targeted therapy, electrochemotherapy and surgery. The increasing number of treatment options that are now available has resulted in a growing need to identify which patients will derive most benefit from which treatments. Much research is now focused on the identification of biomarkers that can be utilised to help select patients for treatment. These and other recent advances in the management of melanoma were the focus of discussions at the third Melanoma Bridge meeting (30 November-2 December, 2017, Naples, Italy), which is summarised in this report.
Earle A. Chiles Research Institute
Ascierto, Paolo A; Puzanov, Igor; Agarwala, Sanjiv S; Bifulco, Carlo; Botti, Gerardo; Caracò, Corrado; Ciliberto, Gennaro; Davies, Michael A; Dummer, Reinhard; Ferrone, Soldano; Gajewski, Thomas F; Garbe, Claus; Luke, Jason J; Marincola, Francesco M; Masucci, Giuseppe; Mehnert, Janice M; Mozzillo, Nicola; Palmieri, Giuseppe; Postow, Michael A; Schoenberger, Stephen P; Wang, Ena; and Thurin, Magdalena, "Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy)." (2018). Articles, Abstracts, and Reports. 533.