Title

Molecularly targeted treatment of recurrent anaplastic astrocytoma - a case report.

Document Type

Article

Publication Date

7-29-2021

Publication Title

Ann Clin Transl Neurol

Keywords

california; santa monica; sjci; psjhc

Abstract

High-grade astrocytomas are malignant and aggressive, with limited treatment options. Treatment is geared not only toward increasing patient's overall survival but also in delaying or preventing neurological disability, a cause of significant morbidity. Increasingly, targeted and customized treatment approaches, especially for recurrent disease, are being explored. Here we present a successful outcome in a young patient with rapidly progressive disease who responded to targeted treatment based on genetic sequencing and circulating tumor DNA markers, given the inaccessibility of the tissue to biopsy. Molecular testing on tissue, serum or CSF may be helpful in identifying unique targets in these complex patients.

Clinical Institute

Neurosciences (Brain & Spine)

Clinical Institute

Cancer

Department

Neurosciences

Department

Oncology

Link to Full Text

PSJH Full Text

Share

COinS