Efficient antigen cross-presentation through coating conventional aluminum adjuvant particles with PEI.
Am J Transl Res
oregon; portland; chiles
Classical aluminum adjuvant is a deficient antigen carrier for cross-presentation and cross-priming of CD8+ cytotoxic T cells. Our previous research has demonstrated that cross-presentation efficiency significantly increased when antigens are conjugated covalently to α-Al2O3 nanoparticles. Here we found that coating conventional aluminum adjuvants with polyethyleneimine (PEI) could enhance antigen cross-presentation of DCs (dendritic cells) in vitro and in vivo. PEIs exerted differential effects on antigen cross-presentation. These findings provided an alternative approach to promote the rapid translation of alumina nanoparticles adjuvants into clinical application.
Earle A. Chiles Research Institute
Pathology & Laboratory Medicine
Ren, Hongyan; Mou, Yongbin; Lin, Lin; Wang, Lixin; and Hu, Hongming, "Efficient antigen cross-presentation through coating conventional aluminum adjuvant particles with PEI." (2021). Articles, Abstracts, and Reports. 5015.