Associations between complete remission and 2- to 3-year survival following 7 + 3 induction for acute myeloid leukemia.
Leukemia & lymphoma
oregon; portland; chiles
Among acute myeloid leukemia (AML) patients treated with 7 + 3 induction, we evaluate the association between complete morphologic remission (CR) and long-term overall survival (OS) over four decades. We analyzed 1247 patients age ≤" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: 0; font-size: 18.08px; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;">≤≤65 randomized to 7 + 3 arms from five SWOG studies. OS has improved over the four decades. Hazards for death in the two most recent studies fell after year 2. In multivariable models, decade of therapy was the most important variable with respect to long-term survival and CR by day 100 the second most important variable. Protocol/decade, which captures many factors not included in our multivariable model, was the most important predictor of being alive at year 2 or 3. The next most important factor was achievement of first CR by day 100.
Earle A. Chiles Research Institute
Othus, Megan; Garcia-Manero, Guillermo; Godwin, John E; Weick, James; Stirewalt, Derek; Appelbaum, Frederick; Erba, Harry; and Estey, Elihu, "Associations between complete remission and 2- to 3-year survival following 7 + 3 induction for acute myeloid leukemia." (2021). Articles, Abstracts, and Reports. 4804.