Annals of the rheumatic diseases
cytokines; dmards (biologic); psoriatic arthritis; treatment
OBJECTIVES: To evaluate the effect of subcutaneous (s.c.) secukinumab, an interleukin-17A inhibitor, on clinical signs and symptoms and radiographic progression in patients with psoriatic arthritis (PsA).
METHODS: Adults (n=996) with active PsA were randomised 2:2:2:3 to s.c. secukinumab 300 mg or 150 mg with loading dose (LD), 150 mg without LD or placebo. All groups received secukinumab or placebo at baseline, weeks 1, 2 and 3 and then every 4 weeks from week 4. The primary endpoint was the proportion of patients achieving an American College of Rheumatology 20 (ACR20) response at week 16.
RESULTS: Significantly more patients achieved an ACR20 response at week 16 with secukinumab 300 mg with LD (62.6%), 150 mg with LD (55.5%) or 150 mg without LD (59.5%) than placebo (27.4%) (p
CONCLUSION: S.c. secukinumab 300 mg and 150 mg with and without LD significantly improved clinical signs and symptoms and inhibited radiographic structural progression versus placebo at week 24 in patients with PsA.
TRIAL REGISTRATION NUMBER: NCT02404350; Results.
Orthopedics & Sports Medicine
Mease, Philip; van der Heijde, Désirée; Landewé, Robert; Mpofu, Shephard; Rahman, Proton; Tahir, Hasan; Singhal, Atul; Boettcher, Elke; Navarra, Sandra; Meiser, Karin; Readie, Aimee; Pricop, Luminita; and Abrams, Ken, "Secukinumab improves active psoriatic arthritis symptoms and inhibits radiographic progression: primary results from the randomised, double-blind, phase III FUTURE 5 study." (2018). Articles, Abstracts, and Reports. 430.