PD-1 Blockade in Anaplastic Thyroid Carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE: Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with
METHODS: We enrolled patients with locally advanced and/or metastatic anaplastic thyroid carcinoma in a phase II cohort of the study. Patients received 400 mg spartalizumab intravenously, once every 4 weeks. The overall response rate was determined according to RECIST v1.1.
RESULTS: Forty-two patients were enrolled. Adverse events were consistent with those previously observed with PD-1 blockade. Most common treatment-related adverse events were diarrhea (12%), pruritus (12%), fatigue (7%), and pyrexia (7%). The overall response rate was 19%, including three patients with a complete response and five with a partial response. Most patients had baseline tumor biopsies positive for PD-L1 expression (n = 28/40 evaluable), and response rates were higher in PD-L1-positive (8/28; 29%) versus PD-L1-negative (0/12; 0%) patients. The highest rate of response was observed in the subset of patients with PD-L1 ≥ 50% (6/17; 35%). Responses were seen in both
CONCLUSION: To our knowledge, this is the first clinical trial to show responsiveness of anaplastic thyroid carcinoma to PD-1 blockade.
Earle A. Chiles Research Institute
Capdevila, Jaume; Wirth, Lori J; Ernst, Thomas; Ponce Aix, Santiago; Lin, Chia-Chi; Ramlau, Rodryg; Butler, Marcus O; Delord, Jean-Pierre; Gelderblom, Hans; Ascierto, Paolo A; Fasolo, Angelica; Führer, Dagmar; Hütter-Krönke, Marie Luise; Forde, Patrick M; Wrona, Anna; Santoro, Armando; Sadow, Peter M; Szpakowski, Sebastian; Wu, Hongqian; Bostel, Geraldine; Faris, Jason; Cameron, Scott; Varga, Andreea; and Taylor, Matthew H, "PD-1 Blockade in Anaplastic Thyroid Carcinoma." (2020). Articles, Abstracts, and Reports. 3774.