Design and synthesis of novel quinic acid derivatives:
Future Med Chem
Aim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA-derivatives against glioblastoma is not well established. Methodology & results: Sixteen novel QA-derivatives and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods. Presence of a tertiary hydroxy and silylether groups in the lead compound were identified for the antitumor activity. QA-16 have 90% inhibition with the IC50 of 10.66 μM and 28.22 μM for LN229 and SNB19, respectively. The induction of apoptosis is faster with the increased fold change of caspase 3/7 and reactive oxygen species. Conclusion: QA-16 and QA-16-NPs shows similar cytotoxicity effect, providing opportunity to use QA-16 as a potential chemotherapeutic agent.
Keywords: PLGA; chemotherapeutic drugs; cytotoxicity; glioblastoma; nanoparticle; quinic acid.
Institute for Systems Biology
Murugesan, Akshaya; Holmstedt, Suvi; Brown, Kenna C; Koivuporras, Alisa; Macedo, Ana S; Nguyen, Nga; Fonte, Pedro; Rijo, Patrícia; Yli-Harja, Olli; Candeias, Nuno R; and Kandhavelu, Meenakshisundaram, "Design and synthesis of novel quinic acid derivatives:" (2020). Articles, Abstracts, and Reports. 3749.