Permanent Pacemaker Implantation After Rapid Deployment Aortic Valve Replacement.
The Annals of thoracic surgery
BACKGROUND: Expandable, rapid deployment aortic valves may interfere with the cardiac conduction system, which can lead to permanent pacemaker implantation (PPI). We sought to characterize PPI after rapid deployment aortic valve replacement with the Edwards Intuity valve system (Edwards Lifesciences, Irvine, CA) and investigate associated factors.
METHODS: We analyzed 708 patients from 29 centers in the Multicenter Experience With Rapid Deployment Edwards Intuity Valve System for Aortic Valve Replacement (TRANSFORM) trial undergoing rapid deployment aortic valve replacement with or without coronary artery bypass graft surgery without preexisting pacemakers. Intrinsic conduction status was recorded as well as PPI incidence through 1 year. The PPI indications were categorized based on expert review of patient PPI source documents. Multivariate analysis was conducted to identify characteristics associated with PPI.
RESULTS: After rapid deployment aortic valve replacement, the PPI incidence through 30 days (PPI
CONCLUSIONS: Patient factors associated with PPI after rapid deployment aortic valve replacement were right bundle branch block, atrioventricular block, female gender, and larger valve size. Interestingly, a strong center-level effect was associated with PPI. This effect may reflect differences in practice patterns, such as postoperative drug management or timing to PPI. These findings provide a deeper understanding of PPI after rapid deployment aortic valve replacement and help guide clinical practice and patient management.
Romano, Matthew A; Koeckert, Michael; Mumtaz, Mubashir A; Slachman, Frank N; Patel, Himanshu J; Chitwood, W Randolph; Barnhart, Glenn R; and Grossi, Eugene A, "Permanent Pacemaker Implantation After Rapid Deployment Aortic Valve Replacement." (2018). Articles, Abstracts, and Reports. 357.