Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
Document Type
Article
Publication Date
9-1-2020
Publication Title
Proceedings of the National Academy of Sciences of the United States of America
Keywords
bioactive lipid; carcinogenesis; cell death; inflammation resolution; soluble epoxide hydrolase
Abstract
Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced apoptosis may trigger escape from dormancy of microtumors by interfering with inflammation resolution and triggering an endoplasmic reticulum (ER) stress response. While eicosanoid and cytokine storms are well-characterized in infection and inflammation, they are poorly characterized in cancer. Here, we demonstrate that carcinogens, such as aflatoxin B
Clinical Institute
Cancer
Department
Institute for Systems Biology
Department
Oncology
Recommended Citation
Fishbein, Anna; Wang, Weicang; Yang, Haixia; Yang, Jun; Hallisey, Victoria M; Deng, Jianjun; Verheul, Sanne M L; Hwang, Sung Hee; Gartung, Allison; Wang, Yuxin; Bielenberg, Diane R; Huang, Sui; Kieran, Mark W; Hammock, Bruce D; and Panigrahy, Dipak, "Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression." (2020). Articles, Abstracts, and Reports. 3495.
https://digitalcommons.providence.org/publications/3495
