Effects of polysubstance exposure on neonatal outcomes for infants with intrauterine opioid exposure.
Journal of perinatology : official journal of the California Perinatal Association
OBJECTIVE: Quantify the effect of prenatal polysubstance exposure on neonatal outcomes compared to methadone exposure alone.
STUDY DESIGN: This retrospective cohort study compared infants with methadone-only exposure to methadone with additional psychoactive substances. Outcomes included time to maximum Finnegan scores, proportion requiring scheduled morphine, and length of stay (LOS).
RESULTS: We identified 323 subjects. The median time to maximum Finnegan score was 38.0 h with 94% peaking within 96 h. Forty-five percent of methadone-only infants were started on scheduled morphine compared to 54% of polysubstance infants (p = 0.10). LOS for polysubstance-exposed infants was 1.30 times longer than infants with methadone-only exposure (95% confidence interval: 1.05, 1.60).
CONCLUSIONS: Exposure to methadone with additional psychoactive substances is associated with longer LOS, but not postnatal morphine use or peak withdrawal symptoms. Most infants experience peak withdrawal symptoms within 4 days and may not benefit from longer observation.
Women & Children
McDaniel, Corrie E; Test, Matthew; Deodhar, Parimal; Jennings, Rebecca; Bove, Joanna; and Carlin, Kristen, "Effects of polysubstance exposure on neonatal outcomes for infants with intrauterine opioid exposure." (2020). Articles, Abstracts, and Reports. 3424.