Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease.
Document Type
Article
Publication Date
8-1-2020
Publication Title
Clinics in liver disease
Abstract
Alpha1-antitrypsin deficiency (A1ATD) is an inherited cause of chronic liver disease. It is inherited in an autosomal codominant pattern with each inherited allele expressed in the formation of the final protein, which is primarily produced in hepatocytes. The disease usually occurs in pediatric and elderly populations. The disease occurs with the accumulation of abnormal protein polymers within hepatocytes that can induce liver injury and fibrosis. It is a commonly under-recognized and underdiagnosed condition. Patients diagnosed with the disease should be regularly monitored for the development of liver disease. Liver transplant is of proven benefit in A1ATD liver disease.
Clinical Institute
Digestive Health
Department
Hepatology
Department
Gastroenterology
Recommended Citation
Manne, Vignan and Kowdley, Kris V, "Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease." (2020). Articles, Abstracts, and Reports. 3410.
https://digitalcommons.providence.org/publications/3410
