Neglected Variables in the Interpretation of Serum Procalcitonin Levels in Patients With Septic Shock.
Document Type
Article
Publication Date
7-21-2020
Publication Title
The Journal of infectious diseases
Abstract
The interpretation of serum procalcitonin (PCT) levels in septic patients is facilitated by reviewing the known stimuli that activate the PCT family of genes. Herein we describe 7 pathways that, alone or in combination, can increase serum PCT levels. As a marker of activation of innate immunity, high PCT levels affect clinical diagnosis, can be trended as a measure of "source" control, and can guide duration of antibacterial therapy in septic patients. Low PCT levels reflect little to no activation of an innate immune response, influence the differential diagnosis, and support the discontinuation of empiric antibiotic therapy. Understanding the pathways that result in elevated serum PCT levels is necessary for interpretation and subsequent clinical management.
Department
Infectious Diseases
Department
Graduate Medical Education
Recommended Citation
Gilbert, David, "Neglected Variables in the Interpretation of Serum Procalcitonin Levels in Patients With Septic Shock." (2020). Articles, Abstracts, and Reports. 3359.
https://digitalcommons.providence.org/publications/3359
