Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
The New England journal of medicine
Adult; Aged; Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renin-Angiotensin System; Treatment Failure; Uric Acid; Xanthine Oxidase
BACKGROUND: Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1 diabetes and early-to-moderate diabetic kidney disease.
METHODS: In a double-blind trial, we randomly assigned participants with type 1 diabetes, a serum urate level of at least 4.5 mg per deciliter, an estimated GFR of 40.0 to 99.9 ml per minute per 1.73 m
RESULTS: A total of 267 patients were assigned to receive allopurinol and 263 to receive placebo. The mean age was 51.1 years, the mean duration of diabetes 34.6 years, and the mean glycated hemoglobin level 8.2%. The mean baseline iohexol-based GFR was 68.7 ml per minute per 1.73 m
CONCLUSIONS: We found no evidence of clinically meaningful benefits of serum urate reduction with allopurinol on kidney outcomes among patients with type 1 diabetes and early-to-moderate diabetic kidney disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; PERL ClinicalTrials.gov number, NCT02017171.).
Kidney & Diabetes
Doria, Alessandro; Galecki, Andrzej T; Spino, Cathie; Pop-Busui, Rodica; Cherney, David Z; Lingvay, Ildiko; Parsa, Afshin; Rossing, Peter; Sigal, Ronald J; Afkarian, Maryam; Aronson, Ronnie; Caramori, M Luiza; Crandall, Jill P; de Boer, Ian H; Elliott, Thomas G; Goldfine, Allison B; Haw, J Sonya; Hirsch, Irl B; Karger, Amy B; Maahs, David M; McGill, Janet B; Molitch, Mark E; Perkins, Bruce A; Polsky, Sarit; Pragnell, Marlon; Robiner, William N; Rosas, Sylvia E; Senior, Peter; Tuttle, Katherine; Umpierrez, Guillermo E; Wallia, Amisha; Weinstock, Ruth S; Wu, Chunyi; Mauer, Michael; PERL Study Group; and Alicic, PERL Study Group Collaborator: Radica, "Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes." (2020). Articles, Abstracts, and Reports. 3311.