Document Type
Article
Publication Date
1-1-2020
Publication Title
Biomark Res
Abstract
Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Exciting developments of gene mutation-targeted therapeutic agents are now changing the landscape in AML treatment. New agents offer more clinical options for patients and also confer a more promising outcome. Since Midostaurin, a FLT3 inhibitor, was first approved by US FDA in 2017 as the first gene mutation-targeted therapeutic agent, an array of new gene mutation-targeted agents are now available for AML treatment. In this review, we will summarize the recent advances in gene mutation-targeted therapies for patients with AML.
Clinical Institute
Cancer
Department
Hematology
Department
Oncology
Recommended Citation
Yu, Jifeng; Jiang, Peter Y Z; Sun, Hao; Zhang, Xia; Jiang, Zhongxing; Li, Yingmei; and Song, Yongping, "Advances in targeted therapy for acute myeloid leukemia." (2020). Articles, Abstracts, and Reports. 3290.
https://digitalcommons.psjhealth.org/publications/3290
