TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking.
Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic and immune therapies. Using preclinical colorectal cancer models in cell type-conditional TGFβ receptor I (ALK5) knockout mice, we interrogate this mechanism. Tumor growth delay and radiation response are unchanged in animals with Treg or macrophage-specific ALK5 deletion. However, CD8αCre-ALK5
Earle A. Chiles Research Institute
Gunderson, Andrew J; Yamazaki, Tomoko; McCarty, Kayla; Fox, Nathaniel E; Phillips, Michaela; Alice, Alejandro F; Blair, Tiffany; Whiteford, Mark; O'Brien, David; Ahmad, Rehan; Kiely, Maria X; Hayman, Amanda; Crocenzi, Todd; Gough, Michael J.; Crittenden, Marka R.; and Young, Kristina H, "TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking." (2020). Articles, Abstracts, and Reports. 2969.