immune checkpoint inhibitors; immunosuppression; immunosuppressive enzymes; immunotherapy; soluble factors; tumor escape; tumor microenvironment
Tumors employ strategies to escape immune control. The principle aim of most cancer immunotherapies is to restore effective immune surveillance. Among the different processes regulating immune escape, tumor microenvironment-associated soluble factors, and/or cell surface-bound molecules are mostly responsible for dysfunctional activity of tumor-specific CD8
Guerrouahen, Bella S; Maccalli, Cristina; Cugno, Chiara; Rutella, Sergio; and Akporiaye, Emmanuel T, "Reverting Immune Suppression to Enhance Cancer Immunotherapy." (2019). Articles, Abstracts, and Reports. 2886.