Reverting Immune Suppression to Enhance Cancer Immunotherapy.

Authors

Bella S Guerrouahen
Cristina Maccalli
Chiara Cugno
Sergio Rutella
Emmanuel T Akporiaye, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USAFollow

Document Type

Article

Publication Date

1-1-2019

Publication Title

Front Oncol

Keywords

immune checkpoint inhibitors; immunosuppression; immunosuppressive enzymes; immunotherapy; soluble factors; tumor escape; tumor microenvironment

Abstract

Tumors employ strategies to escape immune control. The principle aim of most cancer immunotherapies is to restore effective immune surveillance. Among the different processes regulating immune escape, tumor microenvironment-associated soluble factors, and/or cell surface-bound molecules are mostly responsible for dysfunctional activity of tumor-specific CD8

Clinical Institute

Cancer

Department

Oncology

Recommended Citation

Guerrouahen, Bella S; Maccalli, Cristina; Cugno, Chiara; Rutella, Sergio; and Akporiaye, Emmanuel T, "Reverting Immune Suppression to Enhance Cancer Immunotherapy." (2019). Articles, Abstracts, and Reports. 2886.
https://digitalcommons.providence.org/publications/2886