Changes in inflammation are related to depression and amount of aerobic exercise in first episode schizophrenia.
Early Interv Psychiatry
BPRS; IL-6; aerobic exercise; depressive symptoms; first episode schizophrenia; inflammation
INTRODUCTION: Elevated levels of pro-inflammatory cytokines have been reported in meta-analyses of multi-episode schizophrenia patients when compared to controls. However, little is known about whether these same relationships are present in the early course of schizophrenia.
OBJECTIVE: To assess first episode schizophrenia patients for depression and to assay blood samples collected at baseline and at 6 months for interleukin-6 (IL-6).
MATERIALS AND METHODS: Trained raters used the Brief Psychiatric Rating Scale to assess depressive symptoms and a standard lab assay kit to assess for IL-6 levels in plasma.
CONCLUSIONS: Decreases in pro-inflammatory IL-6 levels were significantly related to decreases in depressive symptoms. Within a subset of patients in a 6-month aerobic exercise protocol, the number of exercise sessions completed was significantly correlated with the amount of decrease in IL-6. The reductions observed in IL-6 with aerobic exercise suggest exercise is a promising intervention to reduce brain inflammation effects in schizophrenia patients.
Neurosciences (Brain & Spine)
Ventura, Joseph; McEwen, Sarah; Subotnik, Kenneth L; Hellemann, Gerhard S; Ghadiali, Manali; Rahimdel, Amir; Seo, Min Jee; Irwin, Michael R; and Nuechterlein, Keith H, "Changes in inflammation are related to depression and amount of aerobic exercise in first episode schizophrenia." (2020). Articles, Abstracts, and Reports. 2870.