Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia.
Document Type
Article
Publication Date
1-27-2020
Publication Title
JCO Oncol Pract
Abstract
PURPOSE: Patients with acute myeloid leukemia with high-risk cytogenetics in first complete remission (CR1) achieve better outcomes if they undergo allogeneic hematopoietic cell transplantation (HCT) compared with consolidation chemotherapy alone. However, only approximately 40% of such patients typically proceed to HCT.
METHODS: We used a prospective organized approach to rapidly identify donors to improve the allogeneic HCT rate in adults with high-risk acute myeloid leukemia in CR1. Newly diagnosed patients had cytogenetics obtained at enrollment, and those with high-risk cytogenetics underwent expedited HLA typing and were encouraged to be referred for consultation with a transplantation team with the goal of conducting an allogeneic HCT in CR1.
RESULTS: Of 738 eligible patients (median age, 49 years; range, 18-60 years of age), 159 (22%) had high-risk cytogenetics and 107 of these patients (67%) achieved CR1. Seventy (65%) of the high-risk patients underwent transplantation in CR1 (
CONCLUSION: Early cytogenetic testing with an organized effort to identify a suitable allogeneic HCT donor led to a CR1 transplantation rate of 65% in the high-risk group, which, in turn, led to an improvement in OS when compared with the OS of patients who did not undergo transplantation.
Clinical Institute
Cancer
Department
Oncology
Recommended Citation
Pagel, John M; Othus, Megan; Garcia-Manero, Guillermo; Fang, Min; Radich, Jerald P; Rizzieri, David A; Marcucci, Guido; Strickland, Stephen A; Litzow, Mark R; Savoie, M Lynn; Spellman, Stephen R; Confer, Dennis L; Chell, Jeffrey W; Brown, Maria; Medeiros, Bruno C; Sekeres, Mikkael A; Lin, Tara L; Uy, Geoffrey L; Powell, Bayard L; Bayer, Ruthee-Lu; Larson, Richard A; Stone, Richard M; Claxton, David; Essell, James; Luger, Selina M; Mohan, Sanjay R; Moseley, Anna; Erba, Harry P; and Appelbaum, Frederick R, "Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia." (2020). Articles, Abstracts, and Reports. 2865.
https://digitalcommons.providence.org/publications/2865
