Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury.

Authors

Julian D Dallmeier
Somayeh Meysami
David A Merrill, The John Wayne Cancer Institute and Pacific Neuroscience Institute, Providence and St. Johns Health Center, Santa Monica, CA, USAFollow
Cyrus A Raji

Document Type

Article

Publication Date

9-1-2019

Publication Title

The British journal of radiology

Keywords

Brain; Brain Injuries, Traumatic; Chronic Traumatic Encephalopathy; Diagnostic Imaging; Humans; Neuroimaging

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is of epidemic proportions in contact sports athletes and is linked to subconcussive and concussive repetitive head impacts (RHI). Although postmortem analysis is currently the only confirmatory method to diagnose CTE, there has been progress in early detection techniques of fluid biomarkers as well as in advanced neuroimaging techniques. Specifically, promising new methods of diffusion MRI and radionucleotide PET scans could aid in the early detection of CTE.The authors examine early detection methods focusing on various neuroimaging techniques. Advances in structural and diffusion MRI have demonstrated the ability to measure volumetric and white matter abnormalities associated with CTE. Recent studies using radionucleotides such as flortaucipir and

Clinical Institute

Neurosciences (Brain & Spine)

Department

Neurosciences

Recommended Citation

Dallmeier, Julian D; Meysami, Somayeh; Merrill, David A; and Raji, Cyrus A, "Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury." (2019). Articles, Abstracts, and Reports. 2775.
https://digitalcommons.providence.org/publications/2775