Mid-Term Outcomes of Transcatheter Aortic Valve Replacement in Extremely Large Annuli With Edwards SAPIEN 3 Valve.
JACC Cardiovasc Interv
OBJECTIVES: The aim of this study was to report the 1-year results of transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 (S3) valve in extremely large annuli.
BACKGROUND: Favorable 30-day outcomes of S3 TAVR in annuli >683 mm
METHODS: From December 2013 to December 2018, 105 patients across 15 centers with mean area 721.3 ± 36.1 mm
RESULTS: The mean age was 76.9 ± 10.4 years, and Society of Thoracic Surgeons predicted risk score averaged 5.2 ± 3.4%. One-year overall mortality and stroke rates were 18.2% and 2.4%, respectively. Quality-of-life index improved from baseline to 30 days and at 1 year (p < 0.001 for both). Mild paravalvular aortic regurgitation occurred in 21.7% of patients, while moderate or greater paravalvular aortic regurgitation occurred in 4.3%. Mild and moderate or severe transvalvular aortic regurgitation occurred in 11.6% and 0%, respectively. Valve gradients remained stable at 1 year.
CONCLUSIONS: S3 TAVR in annular areas >683 mm
Sengupta, Aditya; Zaid, Syed; Kamioka, Norihiko; Terre, Juan; Miyasaka, Masaki; Hirji, Sameer A; Hensey, Mark; Geloo, Nadim; Petrossian, George; Robinson, Newell; Sarin, Eric; Ryan, Liam; Yoon, Sung-Han; Tan, Christina W; Khalique, Omar K; Kodali, Susheel K; Kaneko, Tsuyoshi; Shah, Pinak B; Wong, S Chiu; Salemi, Arash; Sharma, Kapil; Kozina, Joseph A; Szerlip, Molly A; Don, Creighton W; Gafoor, Sameer; Zhang, Ming; Newhart, Zachary; Kapadia, Samir R; Mick, Stephanie L; Krishnaswamy, Amar; Kini, Annapoorna; Ahmad, Hasan; Lansman, Steven L; Mack, Michael J; Webb, John G; Babaliaros, Vasilis; Thourani, Vinod H; Makkar, Raj R; Leon, Martin B; George, Isaac; and Tang, Gilbert H L, "Mid-Term Outcomes of Transcatheter Aortic Valve Replacement in Extremely Large Annuli With Edwards SAPIEN 3 Valve." (2020). Articles, Abstracts, and Reports. 2743.