The safety and feasibility of minimally invasive sentinel lymph node staging using indocyanine green in the management of endometrial cancer.

Authors

Alberto A Mendivil, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United StatesFollow
Lisa N Abaid, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United StatesFollow
John V Brown, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United States
Kristina M Mori, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United StatesFollow
Tiffany L Beck, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United StatesFollow
Howard D Epstein, Hoag Hospital, Department of Pathology, Newport Beach, CA 92663, United States
John P Micha, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United States
Bram H Goldstein, Gynecologic Oncology Associates, Hoag Memorial Hospital Cancer Center, Newport Beach, CA 92663, United States

Document Type

Article

Publication Date

5-1-2018

Publication Title

European journal of obstetrics, gynecology, and reproductive biology

Keywords

Disease staging; Endometrial cancer; Indocyanine green; Sentinel lymph node mapping; Adult; Aged; Aged, 80 and over; Carcinoma, Endometrioid/pathology; Carcinoma, Endometrioid/surgery; Coloring Agents; Endometrial Neoplasms/pathology; Endometrial Neoplasms/surgery; Feasibility Studies; Female; Humans; Indocyanine Green; Lymphatic Metastasis; Middle Aged; Minimally Invasive Surgical Procedures; Neoplasm Staging; Retrospective Studies; Sentinel Lymph Node/pathology; Sentinel Lymph Node Biopsy/methods; Sentinel Lymph Node Biopsy/statistics & numerical data

Abstract

OBJECTIVES: The purpose of this study was to report on the feasibility of laparoscopic sentinel lymph node (SLN) staging using indocyanine green (ICG) in the management of endometrial cancer.

STUDY DESIGN: We retrospectively evaluated the charts of presumed, clinical stage I endometrial cancer patients who underwent robotic-assisted surgery that incorporated mapping with ICG and SLN dissection from January 2016 until February 2017. Patient demographics, operative characteristics (e.g., complications, lymph node counts) and pathology data were evaluated.

RESULTS: There were 87 patients who were included in the study. A total of 370 lymph nodes were removed, of which 245 were SLNs; unilateral and bilateral mapping of the SLNs was achieved in 84 (96.5%) and 71 (81.6%) of subjects, respectively. There were 10 (11.5%) patients who had metastatic disease identified within 22 (5.9%) of the total (n = 370) lymph nodes extracted, 19 (7.7%) of which were sentinel lymph nodes. We did not observe any intraoperative complications.

CONCLUSION: The results from our study suggest that minimally invasive SLN staging using ICG is a feasible procedure that is potentially effective at detecting metastases, which may ultimately attenuate the incidence of surgical morbidity.

Clinical Institute

Cancer

Clinical Institute

Women & Children

Department

Obstetrics & Gynecology

Department

Oncology

Recommended Citation

Mendivil, Alberto A; Abaid, Lisa N; Brown, John V; Mori, Kristina M; Beck, Tiffany L; Epstein, Howard D; Micha, John P; and Goldstein, Bram H, "The safety and feasibility of minimally invasive sentinel lymph node staging using indocyanine green in the management of endometrial cancer." (2018). Articles, Abstracts, and Reports. 256.
https://digitalcommons.providence.org/publications/256