Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.
Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or
Institute for Systems Biology
Chen, Guo; Park, Dongkyoo; Magis, Andrew T; Behera, Madhusmita; Ramalingam, Suresh S; Owonikoko, Taofeek K; Sica, Gabriel L; Ye, Keqiang; Zhang, Chao; Chen, Zhengjia; Curran, Walter J; and Deng, Xingming, "Mcl-1 Interacts with Akt to Promote Lung Cancer Progression." (2019). Articles, Abstracts, and Reports. 2532.