Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.
Document Type
Article
Publication Date
12-15-2019
Publication Title
Cancer research
Abstract
Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or
Clinical Institute
Cancer
Department
Oncology
Department
Institute for Systems Biology
Recommended Citation
Chen, Guo; Park, Dongkyoo; Magis, Andrew T; Behera, Madhusmita; Ramalingam, Suresh S; Owonikoko, Taofeek K; Sica, Gabriel L; Ye, Keqiang; Zhang, Chao; Chen, Zhengjia; Curran, Walter J; and Deng, Xingming, "Mcl-1 Interacts with Akt to Promote Lung Cancer Progression." (2019). Articles, Abstracts, and Reports. 2532.
https://digitalcommons.providence.org/publications/2532
