Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro.

Authors

Donald J Messner
Todd Robinson
Kris V Kowdley, Organ Care Research and Liver Care Network , Swedish Medical Center , Seattle , Washington , USA. AbstractFollow

Document Type

Article

Publication Date

4-1-2017

Publication Title

Nutrition and cancer

Keywords

Animals; Antioxidants; Carcinogens; Cells, Cultured; Curcuma; Curcumin; Epithelial Cells; Ferric Compounds; Iron; Iron Overload; Liver; Liver Neoplasms; Oxidative Stress; Plant Extracts; Quaternary Ammonium Compounds; Rats

Abstract

Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC

Clinical Institute

Cancer

Department

Oncology

Recommended Citation

Messner, Donald J; Robinson, Todd; and Kowdley, Kris V, "Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro." (2017). Articles, Abstracts, and Reports. 2388.
https://digitalcommons.providence.org/publications/2388