The State of Systems Genetics in 2017.
Animals; Drug Discovery; Genetics; Genomics; Genotype; Humans; Microbiota; Multifactorial Inheritance; Phenotype; Systems Biology
Cell Systems invited 16 experts to share their views on the field of systems genetics. In questions repeated in the headings, we asked them to define systems genetics, highlight its relevance to researchers outside the field, discuss what makes a strong systems genetics paper, and paint a picture of where the field is heading in the coming years. Their responses, ordered by the journal but otherwise unedited, make it clear that deciphering genotype to phenotype relationships is a central challenge of systems genetics and will require understanding how networks and higher-order properties of biological systems underlie complex traits. In addition, our experts illuminate the applications and relevance of systems genetics to human disease, the gut microbiome, development of tools that connect the global research community, sustainability, drug discovery, patient-specific disease and network models, and personalized treatments. Finally, a table of suggested reading provides a sample of influential work in the field.
Institute for Systems Biology
Baliga, Nitin S; Björkegren, Johan L M; Boeke, Jef D; Boutros, Michael; Crawford, Nigel P S; Dudley, Aimée M; Farber, Charles R; Jones, Allan; Levey, Allan I; Lusis, Aldons J; Mak, H Craig; Nadeau, Joseph H; Noyes, Marcus B; Petretto, Enrico; Seyfried, Nicholas T; Steinmetz, Lars M; and Vonesch, Sibylle C, "The State of Systems Genetics in 2017." (2017). Articles, Abstracts, and Reports. 2385.