Age Factors; Age of Onset; Aged; Alzheimer Disease; Apolipoproteins E; Female; Follow-Up Studies; Genetic Association Studies; House Calls; Humans; Male; Polymorphism, Single Nucleotide; Principal Component Analysis; Prospective Studies; Receptors, Complement 3b; Research Design; Sex Factors; Superior Sagittal Sinus; Ascertainment bias; Bias; Cohort studies; Genetics; Genome-wide association studies; Genome-wide studies; Home research study visits; Inference; Late-onset Alzheimer's disease; Longitudinal studies; Missing data; Population-based studies; Prospective studies; Research clinic study visits; Selection bias
INTRODUCTION: Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.
METHODS: We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.
RESULTS: LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction.
DISCUSSION: Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.
Neurosciences (Brain & Spine)
Fardo, David W; Gibbons, Laura E; Mukherjee, Shubhabrata; Glymour, M Maria; McCormick, Wayne; McCurry, Susan M; Bowen, James D; Larson, Eric B; and Crane, Paul K, "Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease." (2017). Articles, Abstracts, and Reports. 2282.